Arterial Medial Calcification through Enhanced small Extracellular Vesicle Release in Smooth Muscle-Specific Asah1 Gene Knockout Mice
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چکیده
منابع مشابه
Smooth Muscle–Selective Nuclear Factor‐κB Inhibition Reduces Phosphate‐Induced Arterial Medial Calcification in Mice With Chronic Kidney Disease
BACKGROUND Hyperphosphatemia is a major factor promoting the formation of arterial medial calcification in chronic kidney disease (CKD). However, arterial medial calcification begins to occur during the early stages of CKD, when hyperphosphatemia is not yet apparent. It is predicted that other factors also play a role. The aim of the present study was to determine the role of pro-inflammatory n...
متن کاملMedial Arterial Calcification
Peripheral arterial disease (PAD) refers to occlusion or narrowing of the upper and lower extremity arteries, causing insufficient blood flow to the limbs. Patients with PAD often present with symptoms, such as claudication, ischemic rest pain, ischemic ulcerations, and limb loss. These patients are also highly predisposed to cardiovascular morbidity and mortality. PAD is underdiagnosed, and li...
متن کاملMedial Arterial Calcification
Peripheral arterial disease (PAD) refers to occlusion or narrowing of the upper and lower extremity arteries, causing insufficient blood flow to the limbs. Patients with PAD often present with symptoms, such as claudication, ischemic rest pain, ischemic ulcerations, and limb loss. These patients are also highly predisposed to cardiovascular morbidity and mortality. PAD is underdiagnosed, and li...
متن کاملMedial Arterial Calcification
Peripheral arterial disease (PAD) refers to occlusion or narrowing of the upper and lower extremity arteries, causing insufficient blood flow to the limbs. Patients with PAD often present with symptoms, such as claudication, ischemic rest pain, ischemic ulcerations, and limb loss. These patients are also highly predisposed to cardiovascular morbidity and mortality. PAD is underdiagnosed, and li...
متن کاملSkeletal muscle dysfunction in muscle-specific LKB1 knockout mice.
Liver kinase B1 (LKB1) is a tumor-suppressing protein that is involved in the regulation of muscle metabolism and growth by phosphorylating and activating AMP-activated protein kinase (AMPK) family members. Here we report the development of a myopathic phenotype in skeletal and cardiac muscle-specific LKB1 knockout (mLKB1-KO) mice. The myopathic phenotype becomes overtly apparent at 30-50 wk of...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-58568-5